Not permitted to relay 550 through this server

I’m loving Mail-in-a-Box. I’m able to send and receive email (all green system status), but a few of my email recipients bounce back, giving me this error message:

550-box.mydomain [my IP]:57395 is currently not permitted to relay 550 through this server. (in reply to RCPT TO command)

How can I tell if this is a problem on my end, or on the end of my recipients’ mail server?

Any advice is much appreciated.

This issue has been solved.