Nginx sometimes not working

Sometimes, box.example.com/mail & /cloud doesnt working -> 503 Gateway timeout.

Adminpage always working.

Nginx-Errorlog:

2017/04/26 10:18:31 [error] 1565#0: *78106 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: x.x.x.x, server: box.example.at, request: “GET /cloud/ HTTP/1.1”, upstream: “fastcgi://unix:/var/run/php5-fpm.sock:”, host: “box.example.at”

2017/04/26 10:18:31 [error] 1564#0: *78138 recv() failed (104: Connection reset by peer) while reading response header from upstream, client: x.x.x.x, server: example.at, request: “POST /Microsoft-Server-ActiveSync?Cmd=Ping&User=claudia%40example.at&DeviceId=android1388534859411&DeviceType=samsungGTI9195 HTTP/1.1”, upstream: “fastcgi://unix:/var/run/php5-fpm.sock:”, host: "example.at"
2017/04/26 10:18:31 [crit] 1564#0: *78152 connect() to unix:/var/run/php5-fpm.sock failed (2: No such file or directory) while connecting to upstream, client: x.x.x.x, server: box.example.at, request: “POST /Microsoft-Server-ActiveSync?Cmd=FolderSync&User=office@example.at&DeviceId=669B2D5361074E4EA81CD2167E7AAFA1&DeviceType=WindowsOutlook15 HTTP/1.1”, upstream: “fastcgi://unix:/var/run/php5-fpm.sock:”, host: “box.example.at”